(R)-PFI 2 hydrochloride | Tocris Bioscience 4892 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(R)-PFI 2 hydrochloride

catalog :

4892

quantity :

10 mg

price :

342 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Judson R, Quarta M, Oudhoff M, Soliman H, Yi L, Chang C, et al. Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential. Cell Stem Cell. 2018;22:177-190.e7 pubmed publisher
Liu X, Chen Z, Xu C, Leng X, Cao H, Ouyang G, et al. Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation. Nucleic Acids Res. 2015;43:5081-98 pubmed publisher
Barsyte Lovejoy D, Li F, Oudhoff M, Tatlock J, Dong A, Zeng H, et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014;111:12853-8 pubmed publisher

product information

brand :

Tocris

master code :

4892

SKU :

4892/10

product name :

(R)-PFI 2 hydrochloride

description :

Potent and selective SETD7 inhibitor

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

535.98

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective SETD7 histone lysine methyltransferase inhibitor (IC50 = 2 nM). Exhibits >1000-fold selectivity over DNMT1 and a panel of 18 other methyltransferases. Inhibits YAP nuclear translocation and function following activation of the Hippo signaling pathway in MCF7 cells. . Negative Control also available.

catalog number base :

4892

product keywords :

(R)-PFI2 HCl potent selective inhibitors inhibits SETD7 lysine histone methyltransferase epigenetics Hippo YAP sgc Lysine Methyltransferases Other Lysine Methyltransferases Hippo/Yap signaling 4892,

extended description :

Potent and selective SETD7 inhibitor

chemical name text :

8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride

formula :

C 23 H 25 F 4 N 3 O 3 S.HCl

formula text :

C23H25F4N3O3S.HCl

cas num :

1627607-87-7

2020 USD :

335

2021 USD :

342 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage