(R)-PFI 2 hydrochloride | Tocris Bioscience 4892/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(R)-PFI 2 hydrochloride

catalog :

4892/10

quantity :

10 mg

price :

400 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Price C, Stavish D, Gokhale P, Stevenson B, Sargeant S, Lacey J, et al. Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition. Dev Cell. 2021;56:2455-2470.e10 pubmed publisher
Judson R, Quarta M, Oudhoff M, Soliman H, Yi L, Chang C, et al. Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential. Cell Stem Cell. 2018;22:177-190.e7 pubmed publisher
Edwards B, Lesnick J, Wang J, Tang N, Peters C. Miniaturization of High-Throughput Epigenetic Methyltransferase Assays with Acoustic Liquid Handling. J Lab Autom. 2016;21:208-16 pubmed publisher
Liu X, Chen Z, Xu C, Leng X, Cao H, Ouyang G, et al. Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation. Nucleic Acids Res. 2015;43:5081-98 pubmed publisher
Barsyte Lovejoy D, Li F, Oudhoff M, Tatlock J, Dong A, Zeng H, et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014;111:12853-8 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4892

SKU :

4892/10

product name :

(R)-PFI 2 hydrochloride

Description :

Potent and selective SETD7 inhibitor

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

535.98

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( R )-PFI 2 hydrochloride is a potent and selective SETD7 histone lysine methyltransferase inhibitor (IC50 = 2 nM). Exhibits >1000-fold selectivity over DNMT1 and a panel of 18 other methyltransferases. Inhibits YAP nuclear translocation and function following activation of the Hippo signaling pathway in MCF7 cells. . Negative Control also available.

extended description :

Potent and selective SETD7 inhibitor

chemical name text :

8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride

formula :

C 23 H 25 F 4 N 3 O 3 S.HCl

formula text :

C23H25F4N3O3S.HCl

cas num :

1627607-87-7

USD :

400 USD

product details :

Potent and selective SETD7 inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage