AR-C 118925XX | Tocris Bioscience 4890/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AR-C 118925XX

catalog :

4890/5

quantity :

5 mg

price :

412 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Corr xea a Velloso J, Bartlett P, Brumer R, Gaspers L, Ulrich H, Thomas A. Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes. iScience. 2021;24:103139 pubmed publisher
Daneva Z, Ottolini M, Chen Y, Klimentova E, Kuppusamy M, Shah S, et al. Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. elife. 2021;10: pubmed publisher
Kountz T, Jairaman A, Kountz C, Stauderman K, Schleimer R, Prakriya M. Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. J Immunol. 2021;207:1275-1287 pubmed publisher
McEwan T, Sophocleous R, Cuthbertson P, Mansfield K, Sanderson Smith M, Sluyter R. Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation. Life Sci. 2021;283:119850 pubmed publisher
Cleary C, Moreira T, Takakura A, Nelson M, Longden T, Mulkey D. Vascular control of the CO2/H+-dependent drive to breathe. elife. 2020;9: pubmed publisher
Tam T, Chan K, Boroumand P, Liu Z, Brozinick J, Bui H, et al. Nucleotides released from palmitate-activated murine macrophages attract neutrophils. J Biol Chem. 2020;295:4902-4911 pubmed publisher
Sophocleous R, Berg T, Finol Urdaneta R, Sluyter V, Keshiya S, Bell L, et al. Pharmacological and genetic characterisation of the canine P2X4 receptor. Br J Pharmacol. 2020;177:2812-2829 pubmed publisher
Sofoluwe A, Bacchetta M, Badaoui M, Kwak B, Chanson M. ATP amplifies NADPH-dependent and -independent neutrophil extracellular trap formation. Sci Rep. 2019;9:16556 pubmed publisher
Sudi S, Tanaka T, Oda S, Nishiyama K, Nishimura A, Sunggip C, et al. TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy. Sci Rep. 2019;9:9785 pubmed publisher
Muoboghare M, Drummond R, Kennedy C. Characterisation of P2Y2 receptors in human vascular endothelial cells using AR-C118925XX, a competitive and selective P2Y2 antagonist. Br J Pharmacol. 2019;176:2894-2904 pubmed publisher
Lu V, Rievaj J, O Flaherty E, Smith C, Pais R, Pattison L, et al. Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat Commun. 2019;10:1029 pubmed publisher
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Jin H, Ko Y, Kim H. P2Y2R-mediated inflammasome activation is involved in tumor progression in breast cancer cells and in radiotherapy-resistant breast cancer. Int J Oncol. 2018;53:1953-1966 pubmed publisher
Pratt S, Hernández Ochoa E, Lee R, Ory E, Lyons J, Joca H, et al. Real-time scratch assay reveals mechanisms of early calcium signaling in breast cancer cells in response to wounding. Oncotarget. 2018;9:25008-25024 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4890

SKU :

4890/5

product name :

AR-C 118925XX

Description :

Selective and competitive P2Y2 antagonist

target :

P2Y Receptor Antagonists

category :

Small Molecules

unit size :

5 mg

purity :

97%

observed molecular weight :

537.59

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AR-C 118925XX is a potent, selective, competitive and reversible P2Y2 receptor antagonist (pA2 = 8.43). Inactive against a panel of 37 other receptors at a concentration of 10 M. AR-C 118925XX inhibits ATP- S-induced mucin secretion in bronchial epithelial cells (IC50 = 1 M). Inhibits P2Y2 receptor-induced -arrestin translocation in vitro (pA2 = 37.2-51.3 nM).

extended description :

Selective and competitive P2Y2 antagonist

chemical name text :

5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide

formula :

C 28 H 23 N 7 O 3 S

formula text :

C28H23N7O3S

cas num :

216657-60-2

USD :

412 USD

product details :

Selective and competitive P2Y2 antagonist

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage