SGC-CBP30 | Tocris Bioscience 4889/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SGC-CBP30

catalog :

4889/10

quantity :

10 mg (also 50 mg)

price :

345 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, et al. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res. 2022;82:3375-3393 pubmed publisher
Meryet Figuière M, Vernon M, Andrianteranagna M, Lambert B, Brochen C, Issartel J, et al. Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects. Cancers (Basel). 2021;13: pubmed publisher
Krstic A, Konietzny A, Halasz M, Cain P, Oppermann U, Kolch W, et al. A Chemo-Genomic Approach Identifies Diverse Epigenetic Therapeutic Vulnerabilities in MYCN-Amplified Neuroblastoma. Front Cell Dev Biol. 2021;9:612518 pubmed publisher
Koh B, Abdul Qayum A, Srivastava R, Fu Y, Ulrich B, Janga S, et al. A conserved enhancer regulates Il9 expression in multiple lineages. Nat Commun. 2018;9:4803 pubmed publisher

image

image 1 :

Cat.No. 4889 - SGC-CBP30 C28H33ClN4O3

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4889

SKU :

4889/10

product name :

SGC-CBP30

Description :

Potent CBP/p300 BRD inhibitor

target :

Bromodomain Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

509.04

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SGC-CBP30 is a potent CBP/p300 bromodomain (BRD) inhibitor (Kd values are 21 and 32 nM for CBP and p300 BRDs respectively). Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Accelerates FRAP recovery in cells at a concentration of 1 M. SGC-CBP30 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

extended description :

Potent CBP/p300 BRD inhibitor

chemical name text :

2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole

formula :

C 28 H 33 ClN 4 O 3

formula text :

C28H33ClN4O3

cas num :

1613695-14-9

USD :

345 USD

product details :

Potent CBP/p300 BRD inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage