CU CPT 22 | Tocris Bioscience 4884/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CU CPT 22

catalog :

4884/10

quantity :

10 mg (also 50 mg)

price :

330 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Yadav S, Singh A, Kant R, Surolia A. TLR4 activation by lysozyme induces pain without inflammation. Front Immunol. 2023;14:1065226 pubmed publisher
Di Lorenzo A, Bolli E, Ruiu R, Ferrauto G, Di Gregorio E, Avalle L, et al. Toll-like receptor 2 promotes breast cancer progression and resistance to chemotherapy. Oncoimmunology. 2022;11:2086752 pubmed publisher
Zhang P, The E, Nedumaran B, Ao L, Jarrett M, Xu D, et al. Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. Int J Biol Sci. 2020;16:3062-3074 pubmed publisher
Ahn H, Han B, Kim J, Kang S, Kim P, Jang K, et al. Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res. 2019;43:291-299 pubmed publisher
Ghonime M, Mitra S, Eldomany R, Wewers M, Gavrilin M. Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. PLoS ONE. 2015;10:e0127278 pubmed publisher

image

image 1 :

Cat.No. 4884 - CU CPT 22 C19H22O7 CAS No. 1416324-85-0

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4884

SKU :

4884/10

product name :

CU CPT 22

Description :

Selective TLR1/2 inhibitor

target :

Toll-like Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

362.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 M). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF- and IL-1 .

extended description :

Selective TLR1/2 inhibitor

chemical name text :

3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester

formula :

C 19 H 22 O 7

formula text :

C19H22O7

cas num :

1416324-85-0

USD :

330 USD

product details :

Selective TLR1/2 inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage