CU CPT 4a | Tocris Bioscience 4883/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CU CPT 4a

catalog :

4883/10

quantity :

10 mg (also 50 mg)

price :

289 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Grigoryeva L, Cianciotto N. Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor. PLoS Pathog. 2021;17:e1009781 pubmed publisher
Zechendorf E, O Riordan C, Stiehler L, Wischmeyer N, Chiazza F, Collotta D, et al. Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI Insight. 2020;5: pubmed publisher

image

image 1 :

Cat.No. 4883 - CU CPT 4a C18H13ClFNO3S CAS No. 1279713-77-7

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4883

SKU :

4883/10

product name :

CU CPT 4a

Description :

Selective TLR3 inhibitor

target :

Toll-like Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

377.82

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CU CPT 4a is a selective TLR3 inhibitor (IC50 = 3.44 M in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF- and IL-1 production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.

extended description :

Selective TLR3 inhibitor

chemical name text :

N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine

formula :

C 18 H 13 ClFNO 3 S

formula text :

C18H13ClFNO3S

cas num :

1279713-77-7

USD :

289 USD

product details :

Selective TLR3 inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage