ML 281 | Tocris Bioscience 4880/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 281

catalog :

4880/10

quantity :

10 mg (also 50 mg)

price :

209 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, et al. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res. 2022;82:3375-3393 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4880

SKU :

4880/10

product name :

ML 281

Description :

STK33 inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

389.47

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits 700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.

extended description :

STK33 inhibitor

chemical name text :

N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide

formula :

C 22 H 19 N 3 O 2 S

formula text :

C22H19N3O2S

cas num :

1404437-62-2

USD :

209 USD

product details :

STK33 inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage