H2L5186303 | Tocris Bioscience 4878/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

H2L5186303

catalog :

4878/10

quantity :

10 mg (also 50 mg)

price :

242 USD

citations: 6

Reference
Ojasalu K, Lieber S, Sokol A, Nist A, Stiewe T, Bullwinkel I, et al. The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis. Theranostics. 2023;13:1921-1948 pubmed publisher
Hirata N, Yamada S, Yanagida S, Ono A, Yasuhiko Y, Nishida M, et al. Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer. Int J Mol Sci. 2022;23: pubmed publisher
Hisaoka Nakashima K, Yokoe T, Watanabe S, Nakamura Y, Kajitani N, Okada Tsuchioka M, et al. Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes. J Neurochem. 2021;158:849-864 pubmed publisher
Wisniewski L, French V, Lockwood N, Valdivia L, Frankel P. P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis. Sci Rep. 2020;10:15589 pubmed publisher
Volden P, Skor M, Johnson M, Singh P, Patel F, McClintock M, et al. Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell Proliferation. Cancer Prev Res (Phila). 2016;9:367-78 pubmed publisher
Wu C, Huang R, Kuo C, Kumar S, Kim C, Lin Y, et al. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circ Res. 2015;117:e41-e53 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4878

SKU :

4878/10

product name :

H2L5186303

description :

Potent and selective LPA2 receptor antagonist

target :

Lysophosphatidic Acid (LPA) Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

488.45

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay).

product keywords :

lysophosphatidic acid 2 receptors LPA2 antagonists Lysophosphatidic Acid Receptors 4878,

extended description :

Potent and selective LPA2 receptor antagonist

chemical name text :

(Z,Z)-4,4 -[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid

formula :

C26H20N2O8

formula text :

C26H20N2O8

cas num :

139262-76-3

USD :

268

USD 2025 :

242 USD

product details :

Potent and selective LPA2 receptor antagonist