product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
CaCCinh-A01
catalog :
4877/10
quantity :
10 mg (also 50 mg)
price :
202 USD
more info or order :
citations: 7
Reference
Dwivedi R, Drumm B, Alkawadri T, Martin S, Sergeant G, Hollywood M, et al. The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells. Eur J Pharmacol. 2023;947:175677 pubmed publisher
Whitlock J, Leikina E, Melikov K, de Castro L, Mattijssen S, Maraia R, et al. Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis. Nat Commun. 2023;14:616 pubmed publisher
Cai W, Makwana R, Straface M, Gharibans A, Andrews P, Sanger G. Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine. Br J Pharmacol. 2022;179:1187-1200 pubmed publisher
Huang J, Lam H, Koziol White C, Limjunyawong N, Kim D, Kim N, et al. The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proc Natl Acad Sci U S A. 2020;117:28485-28495 pubmed publisher
He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, et al. Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nat Commun. 2020;11:2165 pubmed publisher
Zaitseva E, Zaitsev E, Melikov K, Arakelyan A, Marin M, Villasmil R, et al. Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine. Cell Host Microbe. 2017;22:99-110.e7 pubmed publisher
Amjad A, Hernandez Clavijo A, Pifferi S, Maurya D, Boccaccio A, Franzot J, et al. Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol. 2015;145:285-301 pubmed publisher
product information
brand :
Tocris, a Bio-Techne Brand
catalog number base :
4877
SKU :
4877/10
product name :
CaCCinh-A01
Description :
Calcium-activated chloride channel (CaCC) inhibitor
target :
Calcium-activated Chloride Channel Blockers
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
347.43
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC50 10 M). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 M, in TMEM16A-expressing FRT cells).
extended description :
Calcium-activated chloride channel (CaCC) inhibitor
chemical name text :
6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
formula :
C 18 H 21 NO 4 S
formula text :
C18H21NO4S
cas num :
407587-33-1
USD :
202 USD
product details :
Calcium-activated chloride channel (CaCC) inhibitor
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK