Eact | Tocris Bioscience 4876/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Eact

catalog :

4876/10

quantity :

10 mg (also 50 mg)

price :

243 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Namkung W, Yao Z, Finkbeiner W, Verkman A. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 2011;25:4048-62 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4876

SKU :

4876/10

product name :

Eact

Description :

Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)

target :

Calcium-activated Chloride Channel Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

428.5

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Eact is a TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 M). Also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 M). Ca2+-independent. Displays no effect on CFTR Cl- or ENaC Na+ conductance. Stimulates submucosal gland secretion in human bronchi.

extended description :

Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)

chemical name text :

3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide

formula :

C 22 H 24 N 2 O 5 S

formula text :

C22H24N2O5S

cas num :

461000-66-8

USD :

243 USD

product details :

Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage