Senexin A | Tocris Bioscience 4875 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Senexin A

catalog :

4875

quantity :

10 mg

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Tang H, Hu Y, Chen C, Xia B, ZIRIN J, Yuan M, et al. The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming. Cell Metab. 2018;27:1040-1054.e8 pubmed publisher
Brägelmann J, Klümper N, Offermann A, von Mässenhausen A, Böhm D, Deng M, et al. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer. Clin Cancer Res. 2017;23:1829-1840 pubmed publisher
Porter D, Farmaki E, Altilia S, Schools G, West D, Chen M, et al. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012;109:13799-804 pubmed publisher

product information

brand :

Tocris

master code :

4875

SKU :

4875/10

product name :

Senexin A

description :

Cdk8 inhibitor

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

310.78

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cyclin-dependent kinase 8 (cdk8) inhibitor (IC50 = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin -induced tumor-promoting paracrine activities in vivo .

catalog number base :

4875

product keywords :

cyclin dependent kinases cdks cdk8 cdk19 inhibits inhibitors p21 transcription Cyclin-dependent Kinase 4875,

extended description :

Cdk8 inhibitor

chemical name text :

4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride

formula :

C 17 H 14 N 4 .HCl

formula text :

C17H14N4.HCl

cas num :

1780390-76-2

2020 USD :

228

2021 USD :

238 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage