product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Senexin A
catalog :
4875/10
quantity :
10 mg
price :
288 USD
more info or order :
citations: 6
Reference
Stieg D, Cooper K, Strich R. The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription. J Biol Chem. 2020;295:16280-16291 pubmed publisher
Rice S, Kim S, Rodriguez C, Songock W, Raikhy G, Lopez R, et al. Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism. Viruses. 2020;12: pubmed publisher
Xue J, Scotti E, Stoffel M. CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. Cell Rep. 2019;28:2892-2904.e7 pubmed publisher
Tang H, Hu Y, Chen C, Xia B, ZIRIN J, Yuan M, et al. The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming. Cell Metab. 2018;27:1040-1054.e8 pubmed publisher
Brägelmann J, Klümper N, Offermann A, von Mässenhausen A, Böhm D, Deng M, et al. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer. Clin Cancer Res. 2017;23:1829-1840 pubmed publisher
Porter D, Farmaki E, Altilia S, Schools G, West D, Chen M, et al. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012;109:13799-804 pubmed publisher
product information
brand :
Tocris, a Bio-Techne Brand
catalog number base :
4875
SKU :
4875/10
product name :
Senexin A
Description :
Cdk8 inhibitor
target :
Cyclin-dependent Kinase Inhibitors
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
310.78
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Senexin A is a cyclin-dependent kinase 8 (cdk8) inhibitor (IC50 = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin -induced tumor-promoting paracrine activities in vivo .
extended description :
Cdk8 inhibitor
chemical name text :
4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
formula :
C 17 H 14 N 4 .HCl
formula text :
C17H14N4.HCl
cas num :
1780390-76-2
USD :
288 USD
product details :
Cdk8 inhibitor
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK