KML 29 | Tocris Bioscience 4872/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KML 29

catalog :

4872/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
VanRyzin J, Marquardt A, Argue K, Vecchiarelli H, Ashton S, Arambula S, et al. Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play. Neuron. 2019;102:435-449.e6 pubmed publisher
Morena M, Leitl K, Vecchiarelli H, Gray J, Campolongo P, Hill M. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. Neuropharmacology. 2016;111:59-69 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4872

SKU :

4872/10

product name :

KML 29

Description :

Highly potent and selective MAGL inhibitor

target :

Monoacylglycerol Lipase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

549.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

KML 29 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and 50 M for 2-AG and AEA respectively).

extended description :

Highly potent and selective MAGL inhibitor

chemical name text :

4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

formula :

C 24 H 21 F 6 NO 7

formula text :

C24H21F6NO7

cas num :

1380424-42-9

USD :

219 USD

product details :

Highly potent and selective MAGL inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage