SR 2211 | Tocris Bioscience 4869/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SR 2211

catalog :

4869/10

quantity :

10 mg

price :

278 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Lopez D, Al Jaberi F, Damas N, Weinert B, Pus U, Torres Rusillo S, et al. Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol. 2021;12:715059 pubmed publisher
Zhang X, Huang Z, Wang J, Ma Z, Yang J, Corey E, et al. Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling. Cancers (Basel). 2021;13: pubmed publisher
Lytle N, Ferguson L, Rajbhandari N, Gilroy K, Fox R, Deshpande A, et al. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell. 2019;177:572-586.e22 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4869

SKU :

4869/10

product name :

SR 2211

Description :

Selective ROR inverse agonist

target :

ROR / NR1F Inverse Agonists

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

527.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor (ROR ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor (LXR ); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of ROR .

extended description :

Selective ROR inverse agonist

chemical name text :

2-Fluoro-4 -[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1 -biphenyl]-4-methanol

formula :

C 26 H 24 F 7 N 3 O

formula text :

C26H24F7N3O

cas num :

1359164-11-6

USD :

278 USD

product details :

Selective ROR inverse agonist

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage