APY 29 | Tocris Bioscience 4865 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

APY 29

catalog :

4865

quantity :

10 mg (also 50 mg)

price :

229 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9:5340 pubmed publisher

product information

brand :

Tocris

master code :

4865

SKU :

4865/10

product name :

APY 29

description :

Inhibits IRE1 autophosphorylation; activates IRE1 endoribonuclease activity

target :

Additional IRE1 Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

332.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Allosteric modulator of IRE1 . Inhibits IRE1 autophosphorylation (IC50 = 280 nM) and activates IRE1 ribonuclease activity.

catalog number base :

4865

product keywords :

APY29 inhibits IRE1a IRE1alpha IRE1 endoribonuclease RNase activates autophosphorylation auto phosphorylation esterases inhibitors activators ER-stress IRE1 4865,

extended description :

Inhibits IRE1 autophosphorylation; activates IRE1 endoribonuclease activity

chemical name text :

N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

formula :

C 17 H 16 N 8

formula text :

C17H16N8

cas num :

1216665-49-4

2020 USD :

222

2021 USD :

229 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage