APY 29 | Tocris Bioscience 4865/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

APY 29

catalog :

4865/10

quantity :

10 mg (also 50 mg)

price :

284 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Park H, Shin D, Sim J, Aum S, Lee M. IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv. 2020;6:eaax9914 pubmed publisher
Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9:5340 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4865

SKU :

4865/10

product name :

APY 29

Description :

Inhibits IRE1 autophosphorylation; activates IRE1 endoribonuclease activity

target :

Additional IRE1 Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

332.36

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

APY 29 is an allosteric modulator of IRE1 . Inhibits IRE1 autophosphorylation (IC50 = 280 nM) and activates IRE1 ribonuclease activity.

extended description :

Inhibits IRE1 autophosphorylation; activates IRE1 endoribonuclease activity

chemical name text :

N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

formula :

C 17 H 16 N 8

formula text :

C17H16N8

cas num :

1216665-49-4

USD :

284 USD

product details :

Inhibits IRE1 autophosphorylation; activates IRE1 endoribonuclease activity

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage