NS 6180 | Tocris Bioscience 4864 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NS 6180

catalog :

4864

quantity :

10 mg (also 50 mg)

price :

149 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Abdulkareem Z, Gee J, Cox C, Wann K. Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Br J Pharmacol. 2016;173:177-90 pubmed publisher

product information

brand :

Tocris

master code :

4864

SKU :

4864/10

product name :

NS 6180

description :

Potent KCa3.1 (IK) channel blocker

target :

Ca2+-Activated Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

323.33

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 M. Potently inhibits IL-2 and IFN- production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

catalog number base :

4864

product keywords :

NS6180 KCa3.1 potassium channels blockers inhibitors inhibits potent inflammatory bowel disease gardos channel KCNN4 anti-inflammatory Ca2+-Activated Potassium Channels 4864,

extended description :

Potent KCa3.1 (IK) channel blocker

chemical name text :

4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

formula :

C 16 H 12 F 3 NOS

formula text :

C16H12F3NOS

cas num :

353262-04-1

2020 USD :

149

2021 USD :

149 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage