CA 074 | Tocris Bioscience 4863/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CA 074

catalog :

4863/1

quantity :

1 mg

price :

202 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Li P, Li Q, Biswas N, Xin H, Diemer T, Liu L, et al. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy. EMBO Mol Med. 2022;14:e14511 pubmed publisher
Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, et al. Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Dev Cell. 2019;49:393-408.e7 pubmed publisher
Li Y, Zhang Y, Gan Q, Xu M, Ding X, Tang G, et al. C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. Protein Cell. 2018;9:1013-1026 pubmed publisher
Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, et al. Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 2012;72:1199-209 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4863

SKU :

4863/1

product name :

CA 074

Description :

Selective cathepsin B inhibitor

target :

Synthetic Cathepsin Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

383.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CA 074 is an inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 M). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

extended description :

Selective cathepsin B inhibitor

chemical name text :

N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline

formula :

C 18 H 29 N 3 O 6

formula text :

C18H29N3O6

cas num :

134448-10-5

USD :

202 USD

product details :

Selective cathepsin B inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage