PPTN hydrochloride | Tocris Bioscience 4862/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PPTN hydrochloride

catalog :

4862/10

quantity :

10 mg

price :

316 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Patritti Cram J, Wu J, Coover R, Rizvi T, Chaney K, Ravindran R, et al. P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis. elife. 2022;11: pubmed publisher
Battistone M, Mendelsohn A, Spallanzani R, Allegretti A, Liberman R, Sesma J, et al. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. J Clin Invest. 2020;130:3734-3749 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4862

SKU :

4862/10

product name :

PPTN hydrochloride

Description :

High affinity and selective P2Y14 antagonist

target :

P2Y Receptor Antagonists

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

511.96

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PPTN hydrochloride is a high affinity and selective P2Y14 antagonist (KB = 434 pM), which exhibits 10,000-fold selectivity for P2Y14 over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690 -induced porcine pancreatic artery contraction ex vivo , and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro .

extended description :

High affinity and selective P2Y14 antagonist

chemical name text :

4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride

formula :

C 29 H 24 F 3 NO 2 .HCl

formula text :

C29H24F3NO2.HCl

cas num :

1992047-65-0

USD :

316 USD

product details :

High affinity and selective P2Y14 antagonist

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage