Amlexanox | Tocris Bioscience 4857 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Amlexanox

catalog :

4857

quantity :

10 mg (also 50 mg)

price :

96 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Alrahbeni T, Sartor F, Anderson J, Miedzybrodzka Z, McCaig C, MÃ¼ller B. Full UPF3B function is critical for neuronal differentiation of neural stem cells. Mol Brain. 2015;8:33 pubmed publisher

product information

brand :

Tocris

master code :

4857

SKU :

4857/10

product name :

Amlexanox

description :

Selective inhibitor of TBK

target :

IkB Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

298.29

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of TANK-binding kinase 1 (TBK1) and IKK (IC50 values are ~1-2 M). Displays no effect on IKK or IKK at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro .

catalog number base :

4857

product keywords :

diabetes obese obesity mouse mice anti-inflammatory anti-inflammatories metabolic disorders diseases IkB kinase IkappaB I B IKK TBK1 TANK-binding kinase 1 noncanonical IkB Kinase NF-kB/IkB Histaminergic-Related Compounds TANK binding kinase (TBK) 4857,

extended description :

Selective inhibitor of TBK

chemical name text :

2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid

formula :

C 16 H 14 N 2 O 4

formula text :

C16H14N2O4

cas num :

68302-57-8

2020 USD :

2021 USD :

96 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage