Amlexanox | Tocris Bioscience 4857/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Amlexanox

catalog :

4857/10

quantity :

10 mg (also 50 mg)

price :

120 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Krivega M, Stiefel C, Karbassi S, Andersen L, Chunduri N, Donnelly N, et al. Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway. Commun Biol. 2021;4:831 pubmed publisher
Shen L, Xiao Y, Xie H, Zhao H, Luo T, Liu L, et al. A naturally derived small molecule NDSM253 inhibits IKK1 to suppress inflammation response and promote bone healing after fracture. Am J Transl Res. 2021;13:24-37 pubmed
Maan M, Agrawal N, Padmanabhan J, Leitzinger C, Rivera Rivera Y, Saavedra H, et al. Tank Binding Kinase 1 modulates spindle assembly checkpoint components to regulate mitosis in breast and lung cancer cells. Biochim Biophys Acta Mol Cell Res. 2021;1868:118929 pubmed publisher
Alrahbeni T, Sartor F, Anderson J, Miedzybrodzka Z, McCaig C, MÃ¼ller B. Full UPF3B function is critical for neuronal differentiation of neural stem cells. Mol Brain. 2015;8:33 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4857

SKU :

4857/10

product name :

Amlexanox

Description :

Selective inhibitor of TBK

target :

IkB Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

298.29

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Amlexanox is a selective inhibitor of TANK-binding kinase 1 (TBK1) and IKK (IC50 values are ~1-2 M). Displays no effect on IKK or IKK at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro .

extended description :

Selective inhibitor of TBK

chemical name text :

2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid

formula :

C 16 H 14 N 2 O 4

formula text :

C16H14N2O4

cas num :

68302-57-8

USD :

120 USD

product details :

Selective inhibitor of TBK

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage