8-pCPT-2-O-Me-cAMP-AM | Tocris Bioscience 4853 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8-pCPT-2-O-Me-cAMP-AM

catalog :

4853

quantity :

100 ug

price :

207 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Mayati A, Moreau A, Le Vee M, Bruyère A, Jouan E, Denizot C, et al. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018;8:16115 pubmed publisher
Mishra R, Belder N, Ansari S, Kayhan M, Bal H, Raza U, et al. Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer. Clin Cancer Res. 2018;24:1987-2001 pubmed publisher
Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, et al. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med. 2015;212:1021-41 pubmed publisher

product information

brand :

Tocris

master code :

4853

SKU :

4853/100U

product name :

8-pCPT-2-O-Me-cAMP-AM

description :

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

target :

EPAC Activators

category :

Small Molecules

unit size :

100 ug

purity :

97%

observed molecular weight :

557.9

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645). . This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

catalog number base :

4853

product keywords :

007-AM cAMP analogs Epac 1 2 epacs activators cell permeable selective Rap guanine nucleotide exchange factor 3 4 RAPGEF cAMP GEFI 007-AM EPAC 4853, EPAC

extended description :

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

chemical name text :

8-(4-Chlorophenylthio)-2 -O-methyladenosine-3 ,5 -cyclic monophosphate acetoxymethyl ester

formula :

C 20 H 21 ClN 5 O 8 PS

formula text :

C20H21ClN5O8PS

cas num :

1152197-23-3

2020 USD :

199

2021 USD :

207 USD

alt names :

007-AM

storage :

Store at -80°C

more info or order :

Tocris Bioscience product webpage