8-pCPT-2-O-Me-cAMP-AM | Tocris Bioscience 4853/100U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8-pCPT-2-O-Me-cAMP-AM

catalog :

4853/100U

quantity :

100 ug

price :

268 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Gao N, Raduka A, Rezaee F. Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin. J Cell Sci. 2022;135: pubmed publisher
Goode D, Molliver D. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci. 2021;41:2883-2898 pubmed publisher
Narayanan V, Schappell L, Mayer C, Duke A, Armiger T, Arsenovic P, et al. Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis. Curr Biol. 2020;30:624-633.e4 pubmed publisher
Kayhan M, Koyas A, Akdemir I, Savas A, Cekic C. Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype. J Immunol. 2019;203:3247-3255 pubmed publisher
Goode D, Molliver D. Phospho-substrate profiling of Epac-dependent protein kinase C activity. Mol Cell Biochem. 2019;456:167-178 pubmed publisher
Mayati A, Moreau A, Le Vee M, Bruyère A, Jouan E, Denizot C, et al. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018;8:16115 pubmed publisher
Kumar N, Prasad P, Jash E, Jayasundar S, Singh I, Alam N, et al. cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer. Carcinogenesis. 2018;39:1245-1253 pubmed publisher
Mishra R, Belder N, Ansari S, Kayhan M, Bal H, Raza U, et al. Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer. Clin Cancer Res. 2018;24:1987-2001 pubmed publisher
Ramos C, Lin C, Liu X, Antonetti D. The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem. 2018;293:717-730 pubmed publisher
Alonge K, Meares G, Hillgartner F. Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4. J Biol Chem. 2017;292:5239-5252 pubmed publisher
Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, et al. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med. 2015;212:1021-41 pubmed publisher
Cyphert H, Alonge K, Ippagunta S, Hillgartner F. Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism. PLoS ONE. 2014;9:e94996 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4853

SKU :

4853/100U

product name :

8-pCPT-2-O-Me-cAMP-AM

description :

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

target :

EPAC Activators

unit size :

100 ug

category :

Small Molecules

purity :

97%

storage :

Store at -20°C

observed molecular weight :

557.9

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645). . This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

product keywords :

007-AM cAMP analogs Epac 1 2 epacs activators cell permeable selective Rap guanine nucleotide exchange factor 3 4 RAPGEF cAMP GEFI 007-AM EPAC 4853, EPAC

extended description :

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

chemical name text :

8-(4-Chlorophenylthio)-2 -O-methyladenosine-3 ,5 -cyclic monophosphate acetoxymethyl ester

formula :

C20H21ClN5O8PS

formula text :

C20H21ClN5O8PS

cas num :

1152197-23-3

USD :

257

USD 2025 :

268 USD

product details :

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

alt names :

007-AM

more info or order :

Tocris Bioscience product webpage