BIX 02189 | Tocris Bioscience 4842 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIX 02189

catalog :

4842

quantity :

10 mg (also 50 mg)

price :

221 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Liang Y, Xing X, Beamer M, Swindell W, Sarkar M, Roberts L, et al. Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders. J Allergy Clin Immunol. 2017;139:1217-1227 pubmed publisher

product information

brand :

Tocris

master code :

4842

SKU :

4842/10

product name :

BIX 02189

description :

Selective MEK5 and ERK5 inhibitor

target :

MEK Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

440.54

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.

catalog number base :

4842

product keywords :

BIX02189 selective MEK5 ERK5 inhibitors inhibits MAPK signaling MEK ERK 4842,

extended description :

Selective MEK5 and ERK5 inhibitor

chemical name text :

(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

formula :

C 27 H 28 N 4 O 2

formula text :

C27H28N4O2

cas num :

1265916-41-3

2020 USD :

216

2021 USD :

221 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage