BIX 02189 | Tocris Bioscience 4842/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIX 02189

catalog :

4842/10

quantity :

10 mg

price :

275 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Craig J, Miller J, Rayavarapu R, Hong Z, Bulut G, Zhuang W, et al. MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation. Cell Death Discov. 2020;6:107 pubmed publisher
Koncar R, Dey B, Stanton A, Agrawal N, Wassell M, McCarl L, et al. Identification of novel RAS signaling therapeutic vulnerabilities in Diffuse Intrinsic Pontine Gliomas. Cancer Res. 2019;: pubmed publisher
Slegtenhorst B, Fajardo Ramírez O, Zhang Y, Dhanerawala Z, Tullius S, Garc xed a Carde xf1 a G. A Mechano-Activated Cell Reporter System as a Proxy for Flow-Dependent Endothelial Atheroprotection. SLAS Discov. 2018;23:869-876 pubmed publisher
Krentz N, Van Hoof D, Li Z, Watanabe A, Tang M, Nian C, et al. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors. Dev Cell. 2017;41:129-142.e6 pubmed publisher
Liang Y, Xing X, Beamer M, Swindell W, Sarkar M, Roberts L, et al. Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders. J Allergy Clin Immunol. 2017;139:1217-1227 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4842

SKU :

4842/10

product name :

BIX 02189

Description :

Selective MEK5 and ERK5 inhibitor

target :

MEK Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

440.54

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIX 02189 is a selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.

extended description :

Selective MEK5 and ERK5 inhibitor

chemical name text :

(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

formula :

C 27 H 28 N 4 O 2

formula text :

C27H28N4O2

cas num :

1265916-41-3

USD :

275 USD

product details :

Selective MEK5 and ERK5 inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage