chemical

KU 0060648

4840

10 mg (also 50 mg)

278 USD

4840

4840/10

KU 0060648

Dual DNA-PK and PI 3-K inhibitor

DNA-dependent Protein Kinase Inhibitors

Small Molecules

10 mg (also 50 mg)

97%

582.71

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Dual PI 3-K and DNA-PK inhibitor (IC50 values are 0.1, 0.5, 4 and 19 nM for PI 3-K , PI 3-K , PI 3-K and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ~2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%; maximum effect seen at 250 nM.

4840

KU0060648 antitumor antitumour PI 3-K phosphoinositide 3-kinases inhibits inhibitors DNA-PK DNA-dependent protein CRISPR Cas9 HDR NHEJ homology directed repair nonhomologous end joining DNA-dependent Protein Kinase PI 3-Kinase Checkpoint Control Kinases CRISPR Reagents 4840,

Dual DNA-PK and PI 3-K inhibitor

4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide

C 33 H 34 N 4 O 4 S

C33H34N4O4S

881375-00-4

267

278 USD

Store at -20°C