KU 0060648 | Tocris Bioscience 4840/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KU 0060648

catalog :

4840/10

quantity :

10 mg (also 50 mg)

price :

345 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4840

SKU :

4840/10

product name :

KU 0060648

Description :

Dual DNA-PK and PI 3-K inhibitor

target :

DNA-dependent Protein Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

582.71

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

KU 0060648 is a dual PI 3-K and DNA-PK inhibitor (IC50 values are 0.1, 0.5, 4 and 19 nM for PI 3-K , PI 3-K , PI 3-K and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ~2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%; maximum effect seen at 250 nM.

extended description :

Dual DNA-PK and PI 3-K inhibitor

chemical name text :

4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide

formula :

C 33 H 34 N 4 O 4 S

formula text :

C33H34N4O4S

cas num :

881375-00-4

USD :

345 USD

product details :

Dual DNA-PK and PI 3-K inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage