AZD 3988 | Tocris Bioscience 4837/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZD 3988

catalog :

4837/10

quantity :

10 mg (also 50 mg)

price :

461 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Wilcock D, Badrock A, Wong C, Owen R, Guerin M, Southam A, et al. Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached. Cell Rep. 2022;39:110995 pubmed publisher
Howie D, Ten Bokum A, Cobbold S, Yu Z, Kessler B, Waldmann H. A Novel Role for Triglyceride Metabolism in Foxp3 Expression. Front Immunol. 2019;10:1860 pubmed publisher
Mahoney C, Pirman D, Chubukov V, Sleger T, Hayes S, Fan Z, et al. A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition. Nat Commun. 2019;10:96 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4837

SKU :

4837/10

product name :

AZD 3988

description :

Potent and selective DGAT-1 inhibitor

target :

Diacylglycerol O-Acyltransferase (DGAT) Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

456.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

product keywords :

AZD3988 potent selective diacylglycerol transferases DGAT1 inhibitors inhibits obesity orally bioavailable cell permeable Diacylglycerol O-Acyltransferase 4837,

extended description :

Potent and selective DGAT-1 inhibitor

chemical name text :

trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid

formula :

C23H22F2N4O4

formula text :

C23H22F2N4O4

cas num :

892489-52-0

USD :

456

USD 2025 :

461 USD

product details :

Potent and selective DGAT-1 inhibitor

more info or order :

Tocris Bioscience product webpage