AZ 628 | Tocris Bioscience 4836/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 628

catalog :

4836/10

quantity :

10 mg (also 50 mg)

price :

301 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Echeverria P, Bhattacharya K, Joshi A, Wang T, Picard D. The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity. PLoS ONE. 2019;14:e0208287 pubmed publisher
Sahu N, Stephan J, Cruz D, Merchant M, Haley B, Bourgon R, et al. Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs. Nat Commun. 2016;7:12351 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4836

SKU :

4836/10

product name :

AZ 628

Description :

Potent Raf kinase inhibitor

target :

Raf Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

451.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZ 628 is a potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.

extended description :

Potent Raf kinase inhibitor

chemical name text :

3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide

formula :

C 27 H 25 N 5 O 2

formula text :

C27H25N5O2

cas num :

878739-06-1

USD :

301 USD

product details :

Potent Raf kinase inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage