LMK 235 | Tocris Bioscience 4830 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LMK 235

catalog :

4830

quantity :

10 mg (also 50 mg)

price :

168 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Lu Y, Stuart J, Talbot Cooper C, Agrawal Singh S, Huntly B, Smid A, et al. Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Proc Natl Acad Sci U S A. 2019;116:11997-12006 pubmed publisher
Chen S, Yin C, Lao T, Liang D, He D, Wang C, et al. AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Cell Cycle. 2015;14:2520-36 pubmed publisher

product information

brand :

Tocris

master code :

4830

SKU :

4830/10

product name :

LMK 235

description :

Selective HDAC4/HDAC5 inhibitor

target :

Class II Histone Deacetylases Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

294.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 M respectively).

catalog number base :

4830

product keywords :

LMK235 histone deacetylases HDAC inhibitors inhibits chemoresistant cancer cytotoxicity Class II HDACs 4830,

extended description :

Selective HDAC4/HDAC5 inhibitor

chemical name text :

N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide

formula :

C 15 H 22 N 2 O 4

formula text :

C15H22N2O4

cas num :

1418033-25-6

2020 USD :

163

2021 USD :

168 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage