TC ASK 10 | Tocris Bioscience 4825 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC ASK 10

catalog :

4825

quantity :

10 mg (also 50 mg)

price :

258 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4825

SKU :

4825/10

product name :

TC ASK 10

description :

Potent and selective ASK1 inhibitor; orally bioavailable

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

432.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 M), MEKK1, TAK1, IKK , ERK1, JNK1, p38 , GSK-3 , PKC and B-raf (IC50 values are 10 M). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.

catalog number base :

4825

product keywords :

TCASK10 apoptosis signal regulating kinase ASK1 potent selective inhibitors inhibits cell permeable active orally bioavailable ASK1 Other ER stress/UPR 4825,

extended description :

Potent and selective ASK1 inhibitor; orally bioavailable

chemical name text :

4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride

formula :

C 21 H 21 N 5 O.2HCl

formula text :

C21H21N5O.2HCl

cas num :

1005775-56-3

2020 USD :

250

2021 USD :

258 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage