PF 03814735 | Tocris Bioscience 4821 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 03814735

catalog :

4821

quantity :

10 mg (also 50 mg)

price :

208 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4821

SKU :

4821/10

product name :

PF 03814735

description :

Aurora kinase A and B inhibitor

target :

Aurora Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

474.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP-competitive inhibitor of Aurora kinases A and B (IC50 values are 0.8 and 5 nM for recombinant Aurora B and Aurora A, respectively). Inhibits phosphorylation of Aurora B, histone H3 and Aurora A in cultured MDA-MB-231 cells (IC50 values are approximately 20, 50 and 150 nM respectively). Shown to block cytokinesis; inhibits cellular proliferation in several human tumor cell lines, including HCT-116, HL-60, A549 and H125, and in human xenograft mouse models. Also enhances adeno-associated virus transduction of retina cells in vitro and in vivo . Orally available.

catalog number base :

4821

product keywords :

PF03814735 Pfizer Aurora kinase A B inhibitors inhibits antiproliferative viral transduction enhancer enhances Aurora Kinases Viral Transduction Enhancers 4821,

extended description :

Aurora kinase A and B inhibitor

chemical name text :

N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-acetamide

formula :

C 23 H 25 F 3 N 6 O 2

formula text :

C23H25F3N6O2

cas num :

942487-16-3

2020 USD :

208

2021 USD :

208 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage