PF 04691502 | Tocris Bioscience 4820 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 04691502

catalog :

4820

quantity :

25 mg

price :

505 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4820

SKU :

4820/25

product name :

PF 04691502

description :

Potent and selective dual PI 3-K/mTOR inhibitor

target :

PI 3-Kinase Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

425.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K , , , , and mTOR, respectively). Displays no significant inhibitory activity at more than 80 protein kinases (concentration 10 M) including hVps34, PI 3-K downstream kinases, and MAPK family members. Orally available. Induces robust cell cycle arrest at the G1 phase in U87MG cancer cells and antitumor activity in SKOV3 ovarian cancer xenograft models.

catalog number base :

4820

product keywords :

PF04691502 phosphoinositide 3-kinases PI 3-K/mTOR mammalian Target Rapamycin FRAP FK506 binding protein 12 FKBP12 rapamycin associated protein cell cycle antitumor PI 3-Kinase mTOR 4820,

extended description :

Potent and selective dual PI 3-K/mTOR inhibitor

chemical name text :

2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one

formula :

C 22 H 27 N 5 O 4

formula text :

C22H27N5O4

cas num :

1013101-36-4

2020 USD :

495

2021 USD :

505 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage