PF 04418948 | Tocris Bioscience 4818 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 04418948

catalog :

4818

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Perkins D, Richard K, Hansen A, Lai W, Nallar S, Koller B, et al. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat Immunol. 2018;19:1309-1318 pubmed publisher
Liu B, Tai Y, Caceres A, Achanta S, Balakrishna S, Shao X, et al. Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. PLoS ONE. 2016;11:e0165200 pubmed publisher
Guillem Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, et al. Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget. 2016;7:32462-77 pubmed publisher
Liu C, Zhu P, Wang W, Li W, Shu Q, Chen Z, et al. Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition. Mol Cell Endocrinol. 2016;424:118-27 pubmed publisher
Wang W, Guo C, Zhu P, Lu J, Li W, Liu C, et al. Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition. Sci Signal. 2015;8:ra106 pubmed publisher

product information

brand :

Tocris

master code :

4818

SKU :

4818/10

product name :

PF 04418948

description :

Potent and selective EP2 receptor antagonist

target :

Prostanoid Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

409.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits 30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 M. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).

catalog number base :

4818

product keywords :

PF04418948 prostanoid receptors EP2 antagonists potent selective PGE2 prostaglandins Prostanoid Receptors 4818,

extended description :

Potent and selective EP2 receptor antagonist

chemical name text :

1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

formula :

C 23 H 20 FNO 5

formula text :

C23H20FNO5

cas num :

1078166-57-0

2020 USD :

207

2021 USD :

216 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage