PF 04418948 | Tocris Bioscience 4818/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 04418948

catalog :

4818/10

quantity :

10 mg (also 50 mg)

price :

230 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Perkins D, Richard K, Hansen A, Lai W, Nallar S, Koller B, et al. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat Immunol. 2018;19:1309-1318 pubmed publisher
Liu B, Tai Y, Caceres A, Achanta S, Balakrishna S, Shao X, et al. Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. PLoS ONE. 2016;11:e0165200 pubmed publisher
Guillem Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, et al. Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget. 2016;7:32462-77 pubmed publisher
Liu C, Zhu P, Wang W, Li W, Shu Q, Chen Z, et al. Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition. Mol Cell Endocrinol. 2016;424:118-27 pubmed publisher
Wang W, Guo C, Zhu P, Lu J, Li W, Liu C, et al. Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition. Sci Signal. 2015;8:ra106 pubmed publisher

product information

brand :

Tocris

catalog number base :

4818

SKU :

4818/10

product name :

PF 04418948

units size :

10 mg (also 50 mg)

description :

Potent and selective EP2 receptor antagonist

target :

Prostanoid Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

409.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 04418948 is a potent prostaglandin E receptor 2 antagonist (PTGER2; EP2; IC50 = 16 nM for human EP2 receptors), which displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors and exhibits 30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 M. PF 04418948 inhibits PGE2-induced increases in intracellular cAMP in vitro and reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).

top caption :

Potent and selective EP2 receptor antagonist

extended description :

Potent and selective EP2 receptor antagonist

chemical name text :

1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

formula :

C23H20FNO5

formula text :

C23H20FNO5

cas num :

1078166-57-0

USD :

230 USD

product details :

Potent and selective EP2 receptor antagonist

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage