SKPin C1 | Tocris Bioscience 4817 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SKPin C1

catalog :

4817

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Brough R, Gulati A, Haider S, Kumar R, Campbell J, Knudsen E, et al. Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer. Oncogene. 2018;37:5701-5718 pubmed publisher
Krämer M, Ribeiro D, Arsenian Henriksson M, Deller T, Rohrer H. Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling. J Neurosci. 2016;36:10425-10439 pubmed

product information

brand :

Tocris

master code :

4817

SKU :

4817/10

product name :

SKPin C1

description :

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

465.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.

catalog number base :

4817

product keywords :

SKPinC1 skp2 SCF E3 ligases p27 accumulation cell cycle arrest inhibits inhibitors antitumor Ubiquitin E3 Ligases Cell Cycle Inhibitors 4817, E3 Ligase

extended description :

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

chemical name text :

2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid

formula :

C 18 H 13 BrN 2 O 4 S 2

formula text :

C18H13BrN2O4S2

cas num :

432001-69-9

2020 USD :

212

2021 USD :

219 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage