FK 866 hydrochloride | Tocris Bioscience 4808 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FK 866 hydrochloride

catalog :

4808

quantity :

10 mg

price :

205 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Singh R, van Haandel L, Heruth D, Ye S, Leeder J, Becker M, et al. Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. J Pharmacol Exp Ther. 2018;365:96-106 pubmed publisher

product information

brand :

Tocris

master code :

4808

SKU :

4808/10

product name :

FK 866 hydrochloride

description :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

target :

NAMPT Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

427.97

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).

catalog number base :

4808

product keywords :

FK866 hydrochloride Nicotinamide phosphoribosyltransferase NMPRTase inhibitors inhibits autophagy apoptosis NAD NAMPT visfatin PBEF Apoptosis Inducers Autophagy NAMPT 4808, PBEF inhibitors, visfatin inhibitors, nicotinamide phosphoribosyltransferase

extended description :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

chemical name text :

2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride

formula :

C 24 H 29 N 3 O 2 .HCl

formula text :

C24H29N3O2.HCl

2020 USD :

197

2021 USD :

205 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage