FK 866 hydrochloride | Tocris Bioscience 4808/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FK 866 hydrochloride

catalog :

4808/10

quantity :

10 mg

price :

238 USD

citations: 1

Reference
Singh R, van Haandel L, Heruth D, Ye S, Leeder J, Becker M, et al. Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. J Pharmacol Exp Ther. 2018;365:96-106 pubmed publisher

product information

brand :

Tocris

master code :

4808

SKU :

4808/10

rank :

0.061

product name :

FK 866 hydrochloride

description :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

target :

NAMPT Inhibitors

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).

extended description :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

chemical name text :

2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride

formula :

C 24 H 29 N 3 O 2 .HCl

formula text :

C24H29N3O2.HCl

cas num :

2727965-45-7

USD :

238 USD

product details :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.