BMS 345541 | Tocris Bioscience 4806 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS 345541

catalog :

4806

quantity :

10 mg (also 50 mg)

price :

270 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Reho J, Guo D, Rahmouni K. Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species. J Am Heart Assoc. 2019;8:e010662 pubmed publisher

product information

brand :

Tocris

master code :

4806

SKU :

4806/10

product name :

BMS 345541

description :

Selective allosteric inhibitor of IKK; anti-inflammatory

target :

IkB Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

291.78

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 M for IKK and IKK respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NF B dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

catalog number base :

4806

product keywords :

BMS345541 Selective IKK allosteric inhibitors inhibits anti-inflammatory IKK IKK arthritis IKK1 IKK2 IkB Kinase NF-kB/IkB 4806,

extended description :

Selective allosteric inhibitor of IKK; anti-inflammatory

chemical name text :

N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

formula :

C 14 H 17 N 5 .HCl

formula text :

C14H17N5.HCl

cas num :

547757-23-3

2020 USD :

259

2021 USD :

270 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage