BMS 345541 | Tocris Bioscience 4806/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS 345541

catalog :

4806/10

quantity :

10 mg (also 50 mg)

price :

313 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Reho J, Guo D, Rahmouni K. Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species. J Am Heart Assoc. 2019;8:e010662 pubmed publisher

product information

brand :

Tocris

master code :

4806

SKU :

4806/10

rank :

0.061

product name :

BMS 345541

description :

Selective allosteric inhibitor of IKK; anti-inflammatory

target :

IkB Kinase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 M for IKK and IKK respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NF B dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

extended description :

Selective allosteric inhibitor of IKK; anti-inflammatory

chemical name text :

N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

formula :

C 14 H 17 N 5 .HCl

formula text :

C14H17N5.HCl

cas num :

547757-23-3

USD :

313 USD

product details :

Selective allosteric inhibitor of IKK; anti-inflammatory

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage