4EGI-1 | Tocris Bioscience 4800 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4EGI-1

catalog :

4800

quantity :

10 mg (also 50 mg)

price :

249 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Riz I, Hawley T, Marsal J, Hawley R. Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget. 2016;7:66360-66385 pubmed publisher
Gkogkas C, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill D, et al. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013;493:371-7 pubmed publisher

product information

brand :

Tocris

master code :

4800

SKU :

4800/10

product name :

4EGI-1

description :

Inhibits eIF4E:eIF4G subunit interaction

target :

Protein-synthesizing GTPase Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

451.28

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

catalog number base :

4800

product keywords :

eIF4E eIF4G inhibitors inhibits interaction cap-dependent translation DNA, RNA and Protein Synthesis Protein-synthesizing GTPases 4800, Protein-synthesizing GTPase Compounds, GTP ase, EC 3.6.5.3, elongation factor, EF, initiation factor, IF, termination factor

extended description :

Inhibits eIF4E:eIF4G subunit interaction

chemical name text :

-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

formula :

C 18 H 12 Cl 2 N 4 O 4 S

formula text :

C18H12Cl2N4O4S

cas num :

315706-13-9

2020 USD :

239

2021 USD :

249 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage