product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
4EGI-1
catalog :
4800/10
quantity :
10 mg (also 50 mg)
price :
319 USD
more info or order :
citations: 6
Reference
Metz J, Hornstein N, Sharma S, Worley J, Gonzalez C, Sims P. High-throughput translational profiling with riboPLATE-seq. Sci Rep. 2022;12:5718 pubmed publisher
Dong Z, Chen W, Chen C, Wang H, Cui W, Tan Z, et al. CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation. Neuron. 2019;: pubmed publisher
Ricciardi S, Manfrini N, Alfieri R, Calamita P, Crosti M, Gallo S, et al. The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling. Cell Metab. 2018;28:895-906.e5 pubmed publisher
Nguyen McCarty M, Klein P. Autophagy is a signature of a signaling network that maintains hematopoietic stem cells. PLoS ONE. 2017;12:e0177054 pubmed publisher
Riz I, Hawley T, Marsal J, Hawley R. Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget. 2016;7:66360-66385 pubmed publisher
Gkogkas C, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill D, et al. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013;493:371-7 pubmed publisher
product information
brand :
Tocris
catalog number base :
4800
SKU :
4800/10
product name :
4EGI-1
units size :
10 mg (also 50 mg)
description :
Inhibits eIF4E:eIF4G subunit interaction
target :
Protein-synthesizing GTPase Compounds
category :
Small Molecules
purity :
98%
observed molecular weight :
451.28
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
review stars :
4
details of functionality :
4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.
top caption :
Inhibits eIF4E:eIF4G subunit interaction
extended description :
Inhibits eIF4E:eIF4G subunit interaction
chemical name text :
-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
formula :
C18H12Cl2N4O4S
formula text :
C18H12Cl2N4O4S
cas num :
315706-13-9
USD :
319 USD
product details :
Inhibits eIF4E:eIF4G subunit interaction
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK