4EGI-1 | Tocris Bioscience 4800/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4EGI-1

catalog :

4800/10

quantity :

10 mg (also 50 mg)

price :

288 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Riz I, Hawley T, Marsal J, Hawley R. Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget. 2016;7:66360-66385 pubmed publisher
Gkogkas C, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill D, et al. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013;493:371-7 pubmed publisher

product information

brand :

Tocris

master code :

4800

SKU :

4800/10

rank :

0.071

product name :

4EGI-1

description :

Inhibits eIF4E:eIF4G subunit interaction

target :

Protein-synthesizing GTPase Compounds

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

extended description :

Inhibits eIF4E:eIF4G subunit interaction

chemical name text :

-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

formula :

C 18 H 12 Cl 2 N 4 O 4 S

formula text :

C18H12Cl2N4O4S

cas num :

315706-13-9

USD :

288 USD

product details :

Inhibits eIF4E:eIF4G subunit interaction

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage