(S)-Duloxetine hydrochloride | Tocris Bioscience 4798 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(S)-Duloxetine hydrochloride

catalog :

4798

quantity :

10 mg (also 50 mg)

price :

64 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Skelly M, Weiner J. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav. 2014;4:468-83 pubmed publisher

product information

brand :

Tocris

master code :

4798

SKU :

4798/10

product name :

(S)-Duloxetine hydrochloride

description :

Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

target :

5-HT Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

333.88

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

catalog number base :

4798

product keywords :

SNRI 5-HT NE norepinephrine noradrenaline reuptake inhibitors inhibits potent high affinity antidepressants anxiolytics orally available 5-HT Transporters Adrenergic Transporters Dopamine Transporters 4798,

extended description :

Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

chemical name text :

(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride

formula :

C 18 H 19 NOS.HCl

formula text :

C18H19NOS.HCl

cas num :

136434-34-9

2020 USD :

2021 USD :

64 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage