(S)-Duloxetine hydrochloride | Tocris Bioscience 4798/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(S)-Duloxetine hydrochloride

catalog :

4798/10

quantity :

10 mg (also 50 mg)

price :

82 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Congiu L, Granato V, Loers G, Kleene R, Schachner M. Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice. Int J Mol Sci. 2022;23: pubmed publisher
Unger E, Keller J, Altermatt M, Liang R, Matsui A, Dong C, et al. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. 2020;183:1986-2002.e26 pubmed publisher
Kruse S, Dayton K, Purnell B, Rosner J, Buchanan G. Effect of monoamine reuptake inhibition and α1 blockade on respiratory arrest and death following electroshock-induced seizures in mice. Epilepsia. 2019;60:495-507 pubmed publisher
Skelly M, Weiner J. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav. 2014;4:468-83 pubmed publisher

product information

brand :

Tocris

catalog number base :

4798

SKU :

4798/10

product name :

(S)-Duloxetine hydrochloride

units size :

10 mg (also 50 mg)

description :

Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

target :

5-HT Transporter Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

333.88

url print :

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details of functionality :

(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

top caption :

Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

extended description :

Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

chemical name text :

(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride

formula :

C18H19NOS.HCl

formula text :

C18H19NOS.HCl

cas num :

136434-34-9

USD :

82 USD

product details :

Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage