ZCL 278 | Tocris Bioscience 4794 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ZCL 278

catalog :

4794

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Bijata M, Labus J, Guseva D, Stawarski M, Butzlaff M, Dzwonek J, et al. Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix. Cell Rep. 2017;19:1767-1782 pubmed publisher
Speranza L, Labus J, Volpicelli F, Guseva D, Lacivita E, Leopoldo M, et al. Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons. J Neurochem. 2017;141:647-661 pubmed publisher
Bijata M, Wlodarczyk J, Figiel I. Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci. 2015;9:199 pubmed publisher
Speranza L, Giuliano T, Volpicelli F, De Stefano M, Lombardi L, Chambery A, et al. Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Front Behav Neurosci. 2015;9:62 pubmed publisher

product information

brand :

Tocris

master code :

4794

SKU :

4794/10

product name :

ZCL 278

description :

Cdc42 inhibitor

target :

Rho GTPase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

95%

observed molecular weight :

584.89

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

catalog number base :

4794

product keywords :

ZCL278 Cdc42 Rho small GTPases inhibitors inhibits Rho 4794,

extended description :

Cdc42 inhibitor

chemical name text :

2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide

formula :

C 21 H 19 BrClN 5 O 4 S 2

formula text :

C21H19BrClN5O4S2

cas num :

587841-73-4

2020 USD :

220

2021 USD :

227 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage