NS 11021 | Tocris Bioscience 4788/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NS 11021

catalog :

4788/10

quantity :

10 mg (also 50 mg)

price :

269 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Bonnycastle K, Kind P, Cousin M. FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis. J Neurosci. 2022;42:1618-1628 pubmed publisher
Bellono N, Leitch D, Julius D. Molecular basis of ancestral vertebrate electroreception. Nature. 2017;543:391-396 pubmed publisher

product information

brand :

Tocris

catalog number base :

4788

SKU :

4788/10

product name :

NS 11021

units size :

10 mg (also 50 mg)

description :

KCa1.1 (BK) channel activator

target :

Ca2+-Activated Potassium Channel Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

511.24

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations 10 M. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the subunit.

top caption :

KCa1.1 (BK) channel activator

extended description :

KCa1.1 (BK) channel activator

chemical name text :

N -[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea

formula :

C16H9BrF6N6S

formula text :

C16H9BrF6N6S

cas num :

956014-19-0

USD :

269 USD

product details :

KCa1.1 (BK) channel activator

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage