PD 0332991 isethionate | Tocris Bioscience 4786/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 0332991 isethionate

catalog :

4786/10

quantity :

10 mg (also 50 mg)

price :

299 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Garcia V, Rushton D, Tom C, Allen N, Kemp P, Svendsen C, et al. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci. 2019;13:669 pubmed publisher

product information

brand :

Tocris

master code :

4786

SKU :

4786/10

rank :

0.051

product name :

PD 0332991 isethionate

description :

Potent cdk4 and cdk6 inhibitor; brain penetrant

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PD 0332991 isethionate is a potent cyclin-dependent kinase 4 (cdk4) and cdk6 inhibitor (IC50 values are 11 nM and 15 nM respectively). Also displays activity at cdk2, cdk5 and cdk9 (IC50 values reported to be 1.6, 1.8 and 0.42-1.1 M, respectively). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines; blocks growth of intracranial glioblastoma multiforme xenografts in mice. Brain penetrant.

extended description :

Potent cdk4 and cdk6 inhibitor; brain penetrant

chemical name text :

6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt

formula :

C 24 H 29 N 7 O 2 .C 2 H 6 O 4 S

formula text :

C24H29N7O2.C2H6O4S

cas num :

827022-33-3

USD :

299 USD

product details :

Potent cdk4 and cdk6 inhibitor; brain penetrant

alt names :

Palbociclib

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage