ANA 12 | Tocris Bioscience 4781/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ANA 12

catalog :

4781/10

quantity :

10 mg (also 50 mg)

price :

268 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Arenas Y, Mart xed nez Garc xed a M, Llansola M, Felipo V. Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia. Int J Mol Sci. 2022;23: pubmed publisher
Soman S, Tingle D, Dagda R, Torres M, Dagda M, Dagda R. Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation. J Neurosci Res. 2021;99:2134-2155 pubmed publisher
Li J, Zhang L, Xu C, Lin Y, Zhang Y, Wu H, et al. Prolonged Use of NMDAR Antagonist Develops Analgesic Tolerance in Neuropathic Pain via Nitric Oxide Reduction-Induced GABAergic Disinhibition. Neurotherapeutics. 2020;17:1016-1030 pubmed publisher
Kim S, Kim N, Lee J, Kim S, Hong J, Son S, et al. Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement. Sci Adv. 2020;6:eaaz9691 pubmed publisher
Livingstone R, Elder M, Barrett M, Westlake C, Peppercorn K, Tate W, et al. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci. 2019;12:198 pubmed publisher
Zhou L, Peng J, Xu Y, Zeng W, Zhang J, Wei X, et al. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. Cell Rep. 2019;27:3844-3859.e6 pubmed publisher
Vickers E, Clark C, Osypenko D, Fratzl A, Kochubey O, Bettler B, et al. Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling. Neuron. 2018;: pubmed publisher
Han W, Zhu Y, Chen B, Liu S, Dang Y. 7,8,3'-Trihydroxyflavone ameliorate oxidative stress in vivo and promotes neurite regeneration in vitro in rat retinal ganglion cells. Eur J Pharmacol. 2018;833:283-289 pubmed publisher
Miao H, Li R, Han C, Lu X, Zhang H. Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats. J Neurophysiol. 2018;120:1307-1317 pubmed publisher
O Neill K, Donohue K, Omelchenko A, Firestein B. The 3' UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor. Front Cell Neurosci. 2018;12:60 pubmed publisher
Hashimotodani Y, Nasrallah K, Jensen K, Chavez A, Carrera D, Castillo P. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 2017;95:928-943.e3 pubmed publisher
Fischer D, Kemp C, Cole Strauss A, Polinski N, Paumier K, Lipton J, et al. Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration. J Neurosci. 2017;37:6786-6796 pubmed publisher
Shamblott M, O Driscoll M, Gomez D, McGuire D. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas. Cell Commun Signal. 2016;14:23 pubmed
Stepan J, Hladky F, Uribe A, Holsboer F, Schmidt M, Eder M. High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit. Front Neural Circuits. 2015;9:70 pubmed publisher

image

image 1 :

Cat.No. 4781 - ANA 12 C22H21N3O3S CAS No. 219766-25-3

product information

brand :

Tocris

MasterCode :

4781

SKU :

4781/10

product name :

ANA 12

target :

Trk Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

407.49

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ANA 12 is a TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 M for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.

extended description :

TrkB receptor antagonist

chemical name text :

N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide

formula :

C 22 H 21 N 3 O 3 S

formula text :

C22H21N3O3S

cas num :

219766-25-3

USD :

268 USD

product details :

TrkB receptor antagonist

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage