BIRT 377 | Tocris Bioscience 4776 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIRT 377

catalog :

4776

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Noor S, Sun M, Vanderwall A, Havard M, Sanchez J, Harris N, et al. LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes. Neuroimmunol Neuroinflamm. 2019;6: pubmed publisher

product information

brand :

Tocris

master code :

4776

SKU :

4776/10

product name :

BIRT 377

description :

Potent negative allosteric modulator of LFA-1

target :

Integrin Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

442.13

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo . Orally available.

catalog number base :

4776

product keywords :

BIRT377 potent negative allosteric modulators LFA-1 lymphocyte function-associated antigen-1 cell adhesion orally available integrins NAM Integrins Cell Adhesion Molecules 4776,

extended description :

Potent negative allosteric modulator of LFA-1

chemical name text :

(5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione

formula :

C 18 H 15 BrCl 2 N 2 O 2

formula text :

C18H15BrCl2N2O2

cas num :

213211-10-0

2020 USD :

218

2021 USD :

227 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage