BIRT 377 | Tocris Bioscience 4776/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIRT 377

catalog :

4776/10

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Mancuso R, Casper J, Schmidt A, Krahenbuhl S, Weitz Schmidt G. Anti-αLβ2 antibodies reveal novel endocytotic cross-modulatory functionality. Br J Pharmacol. 2020;177:2696-2711 pubmed publisher
Noor S, Sun M, Vanderwall A, Havard M, Sanchez J, Harris N, et al. LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes. Neuroimmunol Neuroinflamm. 2019;6: pubmed publisher

product information

brand :

Tocris

master code :

4776

SKU :

4776/10

rank :

0.061

product name :

BIRT 377

description :

Potent negative allosteric modulator of LFA-1

target :

Integrin Receptor Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIRT 377 is a potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). BIRT 377 binds to the I-domain of LFA-1. BIRT 377 reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. BIRT 377 inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo . Orally available.

extended description :

Potent negative allosteric modulator of LFA-1

chemical name text :

(5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione

formula :

C 18 H 15 BrCl 2 N 2 O 2

formula text :

C18H15BrCl2N2O2

cas num :

213211-10-0

USD :

264 USD

product details :

Potent negative allosteric modulator of LFA-1

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage